Pseudomonas aeruginosa proteolytically alters the interleukin 22-dependent lung mucosal defense
نویسندگان
چکیده
منابع مشابه
Role of Interleukin-17 in defense against pseudomonas aeruginosa infection in lungs.
BACKGROUND Pseudomonas aeruginosa may cause severe or even fatal infection in hosts with immunodeficiency. Interleukin-17 (IL-17) is a newly discovered pro-inflammatory cytokine, which promotes the recruitment and activation of neutrophils in the respiratory tract by inducing release of chemokine C-X-C. OBJECTIVE This study was conducted to explore the role of IL-17 in host defense against ac...
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Neutrophil serine proteases (NSPs; elastase, cathepsin G, and proteinase-3) directly kill invading microbes. However, excess NSPs in the lungs play a central role in the pathology of inflammatory pulmonary disease. We show that serpinb1, an efficient inhibitor of the three NSPs, preserves cell and molecular components responsible for host defense against Pseudomonas aeruginosa. On infection, wi...
متن کاملRole of pulmonary alveolar macrophages in defense of the lung against Pseudomonas aeruginosa.
Alveolar macrophages (AM) provide one of the first lines of defense against microbial invasion in the lower airways. The role of AM in the clearance of Pseudomonas aeruginosa in mice after intrapulmonary challenge was evaluated. AM were depleted by intranasal administration of liposome-encapsulated dichloromethylene diphosphonate. At 24 h following the instillation of liposomes, a sublethal dos...
متن کاملRedundant and cooperative interactions between TLR5 and NLRC4 in protective lung mucosal immunity against Pseudomonas aeruginosa.
Flagellin is the major structural component of flagella expressed by Pseudomonas aeruginosa (PA) and other bacteria. This protein has been shown to activate the Toll-like receptor TLR5 and the Nod-like receptor Nlrc4/Ipaf, culminating in the expression of innate cytokines and antimicrobial molecules. In this study, we tested the hypothesis that TLR5 and Nlrc4 in combination are required for max...
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ژورنال
عنوان ژورنال: Virulence
سال: 2016
ISSN: 2150-5594,2150-5608
DOI: 10.1080/21505594.2016.1253658